If you've ever dealt with occasional heartburn, indigestion, or an unsettled stomach after meals, you know how disruptive digestive discomfort can be. Many people turn to deglycyrrhizinated licorice (DGL) for gentle, natural stomach support. DGL is a form of licorice root that has had the compound glycyrrhizin removed, making it safer for long-term use while still helping to soothe and protect the stomach lining. In this guide, we evaluate the best DGL supplements for digestive support, focusing on purity, potency, and additional benefits. Whether you prefer classic chewable tablets or a modern blend with adaptogens, we have you covered. If you want to understand how digestive aids work at a deeper level, check out our complete guide on how digestive enzymes work for more context.
Pros
- Specialized DGL formulation protects stomach lining without side effects of regular licorice
- Highly rated for digestive support, with a 4.9-star average from users
- Clean label: vegan, gluten-free, dairy-free, and free from major allergens
- Rigorous third-party testing for safety and purity
Cons
- Chewable tablets may not be suitable for those who dislike licorice flavor
- Requires consistent pre-meal timing for best results
- Limited to digestive health benefits; not a multi-purpose supplement
Natural Factors DGL Licorice 400 mg chewable tablets are a targeted digestive supplement designed for anyone seeking gentle, natural support for stomach and intestinal health. Unlike standard licorice root, this deglycyrrhizinated formula (DGL) removes glycyrrhizin, making it safe for long-term use without affecting blood pressure. It’s an excellent choice for individuals with occasional indigestion, heartburn, or those wanting to maintain a healthy gut lining.
The standout feature is the chewable form, which allows the active compounds to begin soothing the stomach immediately. Each tablet delivers 400 mg of DGL licorice extract, and taking one to three tablets 20 minutes before meals helps reinforce the mucosal barrier. Users report noticeable relief from discomfort, especially when taken consistently. The natural sweetness from licorice makes the tablets palatable, though the flavor may take some getting used to.
Build quality is impressive: Natural Factors, a family-owned company for over six decades, subjects every batch to ISURA third-party testing for more than 800 contaminants. The tablets are vegan, free from gluten, dairy, soy, and GMOs, which aligns with clean-label preferences. The 180-count bottle offers a two- to three-month supply at the recommended dosage, providing good value for daily use.
One potential drawback is the specific taste of licorice, which some may find strong or medicinal. Additionally, the product’s benefits are focused on digestive support; it’s not a broad-spectrum supplement. Users with severe conditions should consult a healthcare professional before use. However, for its intended purpose, the DGL formula stands out as a targeted, effective solution.
Overall, Natural Factors DGL Licorice 400 mg chewable tablets earn high marks for purity, efficacy, and clean formulation. If you’re looking for a gentle digestive aid that supports your stomach lining without additives or allergens, this supplement is a trustworthy choice. Its strong ratings and rigorous testing make it a top pick in the licorice root category.
Pros
- Liquid formulation may offer faster absorption compared to dry capsules
- Adaptogenic herbs add stress-relief benefits beyond basic licorice root
- Easy-to-swallow capsule design simplifies daily use
- Natural ingredients align with clean-label preferences
- Designed for long-term digestive comfort without harsh effects
Cons
- No customer reviews yet makes it hard to gauge real-world experience
- Sediment inside capsules may be off-putting to some users, though normal
- Price point is moderate compared to basic licorice root supplements
The HesperiIyntis DGL Licorice supplement is a thoughtfully formulated blend that goes beyond basic licorice root. Designed for those who experience occasional stomach discomfort linked to stress, it combines deglycyrrhizinated licorice (DGL) with adaptogens like ashwagandha, rhodiola, and holy basil. This makes it a dual-purpose product for digestive and emotional well-being, ideal for anyone looking to support their gut and stress levels in one daily capsule.
Standout features include its liquid-filled capsule format, which delivers a concentrated botanical extract without the need for multiple pills. The addition of adaptogens targets the gut-brain axis, offering a more holistic approach than standard DGL products. While performance data is limited due to zero reviews, the ingredient profile is grounded in traditional herbal use and modern adaptogenic research, promising a gentle yet effective routine for everyday stomach comfort.
Build quality appears solid: the capsules are easy to swallow and the liquid formula ensures consistent dosing. HesperiIyntis emphasizes natural botanical quality, noting that slight sediment may form inside the capsules over time. This is a normal characteristic of plant extracts and does not impact potency or safety, though it may surprise new users.
Potential drawbacks include the lack of customer feedback, which makes it difficult to assess real-world results. Additionally, the adaptogen blend may not appeal to purists wanting only licorice root. The price is reasonable given the dual-action formula, but budget-conscious shoppers might find cheaper alternatives with simpler ingredients.
Overall, this DGL licorice capsule is a well-conceived option for those seeking a comprehensive digestive support that also addresses stress-related triggers. It is best suited for individuals who value botanical synergy and convenience. If you're open to a multi-ingredient approach, HesperiIyntis offers a promising addition to your daily wellness routine.
Pros
- High potency (60 billion CFU) for robust gut support.
- Includes organic prebiotics to enhance probiotic effectiveness.
- Acid-resistant capsules ensure survival through the digestive tract.
- Third-party tested for purity and potency, ensuring quality.
- Suitable for both men and women, addressing common digestive issues.
Cons
- May cause initial digestive discomfort (gas, bloating) as your gut adjusts.
- Some users may prefer a higher CFU count (e.g., 100 billion) for severe gut issues.
- Requires daily consistency to see full benefits; results may take a few weeks.
The Physician's CHOICE Probiotics 60 Billion CFU is a high-strength supplement designed to support digestive and immune health. It's suitable for both men and women who experience occasional constipation, diarrhea, gas, or bloating. With a potent blend of 10 probiotic strains and organic prebiotics, this product aims to restore gut balance and promote overall well-being.
Standout features include its 60 billion colony-forming units (CFU) per serving, which is a substantial dose for daily maintenance. The inclusion of organic prebiotics helps feed the beneficial bacteria, enhancing their survival and colonization. The acid-resistant capsules and shelf-stable bottle ensure that the probiotics reach your intestines alive, maximizing their effectiveness. This is a key advantage over many competing products that may not survive stomach acid.
In terms of design and build quality, the product comes in a compact, airtight bottle that protects the probiotics from moisture and heat. The capsules are easy to swallow, and the packaging clearly lists all ingredients and CFU count. The brand's commitment to third-party testing and manufacturing in the USA adds to its credibility, ensuring purity and potency.
While the product is generally well-tolerated, some users may experience initial digestive discomfort such as gas or bloating as their gut microbiome adjusts. This is common with high-potency probiotics and typically subsides within a few days. Additionally, individuals with severe gut issues may require a higher CFU count or a more targeted strain blend, but for general digestive support, this product is excellent.
Overall, the Physician's CHOICE Probiotics 60 Billion CFU is a reliable and effective choice for anyone looking to improve their gut health. Its potent formula, combined with prebiotics and acid-resistant delivery, makes it a standout in the market. I recommend it for those seeking a science-backed probiotic to support digestion and immunity.
Brand: Physician's CHOICE
Count: 30 capsules (one-month supply)
CFU: 60 billion per serving
Strains: 10 diverse probiotic strains
Prebiotics: Organic prebiotics included
Form: Capsule, shelf-stable
Dimensions: 4.5 x 2.4 x 2.4 inches
Weight: 0.15 pounds
Country of Origin: USA
Third-party tested: Yes
Pros
- Comprehensive digestive support with 16 enzymes and prebiotics/probiotics.
- Soil-based probiotics are resilient and survive stomach acid.
- Third-party tested for purity and potency.
- No refrigeration required, convenient for on-the-go.
- Suitable for various diets including vegetarian.
Cons
- Some users may prefer a higher probiotic count or specific strains.
- Capsules may be large for those with difficulty swallowing.
- Results may vary depending on individual digestive issues.
Physician's CHOICE Digestive Enzymes are a comprehensive supplement designed to alleviate bloating and discomfort after meals. This 60-count bottle contains a powerful blend of 16 enzymes plus organic prebiotics and soil-based probiotics, making it ideal for anyone seeking digestive support, especially those with diverse diets.
The dual-action formula works by breaking down food with enzymes while prebiotics and probiotics support gut health. The soil-based probiotic strains are specially selected for their ability to survive stomach acid, ensuring they reach the gut alive. This science-backed approach is reviewed by expert physicians, adding credibility.
Manufactured in the USA with strict quality control, each batch is third-party tested for purity and potency. The capsules require no refrigeration, making them convenient for daily use at home or while traveling. The packaging is compact and easy to store.
While the formula covers a wide range of food types, some users may find the enzyme count lower than specialized formulas. Additionally, the capsules might be large for some individuals. As with any supplement, individual results may vary.
Overall, Physician's CHOICE Digestive Enzymes offer a well-rounded solution for digestive health. With its blend of enzymes, prebiotics, and resilient probiotics, it provides effective relief from bloating and discomfort. It is a trustworthy choice backed by quality assurance and expert input.
Size: 60 Count (Pack of 1)
Dimensions: 2.31 x 2.31 x 4.5 inches
Weight: 0.18 pounds
Product Group: Drugstore
Binding: Health and Beauty
Buying Guide: What to Look for in a DGL Supplement
Choosing the right DGL product means considering a few key factors. Not all supplements are created equal, and your personal preferences and health goals will guide your decision. Below are the most important criteria to keep in mind.
Form and Ease of Use
DGL supplements come in several forms, including chewable tablets, capsules, and liquid-filled capsules. Chewable tablets are the most traditional and are often recommended because they begin working in the mouth and throat, coating the digestive tract as you chew. Capsules are convenient for those who prefer a tasteless option, while liquid-filled capsules offer a modern twist with easy absorption. For daily digestive support, many users prefer the chewable route for its direct soothing effect. If you are looking for other digestive aids, our review of the best peppermint oil supplements may be helpful.
Potency and Purity
The concentration of DGL per serving matters. Most products offer around 400 mg per tablet, which is a standard effective dose. Look for supplements that use verified ingredients and avoid unnecessary fillers, artificial colors, or common allergens. Brands that are third-party validated for quality give you extra confidence. Natural Factors, for instance, subjects every batch to rigorous checks for over 800 contaminants. Always choose a product that clearly states its active ingredient dose and confirms it is free from GMOs, gluten, and other additives you may want to avoid.
Additional Ingredients and Synergy
Some DGL supplements go beyond licorice root by blending in adaptogenic herbs like ashwagandha, rhodiola, and holy basil. These botanicals help balance the body's stress response, which can indirectly support digestive wellness since stress often triggers stomach discomfort. If you experience digestive issues linked to anxiety or tension, a combination formula may offer broader relief. On the other hand, if you want a pure, straightforward DGL supplement, stick with a single-ingredient product. For more on soothing the gut naturally, you might enjoy our guide to the best fennel supplements for digestion.
It is included here for completeness but is not a DGL supplement. If you are specifically looking for stomach and gut support, focus on the three DGL options reviewed above.
Final Thoughts
After reviewing the top options, our recommendation is straightforward. For those seeking a reliable, high-potency DGL that you can chew before meals for immediate soothing, the Natural Factors DGL Licorice 400 mg (180-count) offers excellent value and purity from a trusted brand. If your digestive discomfort is often tied to stress, the DGL Licorice, Licorice Root Extract for Digestive & Emotional blend adds adaptogens that address both gut calm and emotional balance. Both products are crafted with care and backed by positive user experiences. Choose the one that best aligns with your lifestyle and digestive needs.
Frequently Asked Questions
What is DGL and how is it different from regular licorice?
DGL stands for deglycyrrhizinated licorice, which means the glycyrrhizin compound has been removed. Glycyrrhizin can cause side effects like high blood pressure when taken in large amounts, so DGL is safer for daily use. Regular licorice candy or supplements with glycyrrhizin are not recommended for extended digestive support.
How does DGL help with digestion?
DGL helps support the natural mucosal lining of the stomach and intestinal walls. It promotes the production of protective mucus and may help soothe irritation. Many people take it 20 minutes before meals to prepare the digestive tract for food. For more on timing supplements effectively, see our article on when to take digestive enzymes.
Is DGL safe to take every day?
Yes, DGL is generally considered safe for daily use when taken as directed. Most products recommend 1 to 3 tablets per day before meals. Because it lacks glycyrrhizin, the risk of side effects is minimal. However, if you have a medical condition or are taking medication, it is always wise to consult a healthcare professional before starting any new supplement in 2026.
Can DGL help with acid reflux or heartburn?
Many people use DGL to relieve occasional heartburn and acid reflux. By coating the esophagus and stomach lining, it can reduce irritation from stomach acid. While not a replacement for prescription treatments, it is a popular natural option for mild symptoms. Choose a chewable form for best results.
