When your stomach feels off, you might wonder whether deglycyrrhizinated licorice (DGL) or slippery elm is the better choice. Both botanicals have a long history of soothing the digestive tract, but they work in slightly different ways. In this guide, we compare three standout products that combine DGL with slippery elm and other complementary ingredients to help you decide which formula fits your routine in 2026.
If you are also considering amino acid support, our L glutamine vs DGL offers more insights.
Pros
- Liposomal delivery may improve bioavailability of active compounds
- Multi-ingredient blend targets different aspects of digestive health
- Easy to use liquid dropper with customizable dosage
- DGL formula is gentler on the system than standard licorice root
- Plant-based and free from common allergens (check label for specifics)
Cons
- Some users may find the taste of liquid herbal extracts unpleasant
- Only 60 servings per bottle may require frequent reordering for daily users
- Limited customer reviews available to gauge real-world effectiveness
The HesperiIyntis Liposomal DGL Licorice Root Extract is a liquid dietary supplement designed to support digestive wellness. It is especially suited for individuals seeking a plant-based alternative to capsules or tablets, with a convenient dropper format that allows precise serving control. The formula combines deglycyrrhizinated licorice root with L-glutamine, marshmallow root, aloe vera, clove bud, slippery elm bark, and capsicum fruit for a broad-spectrum approach to gut health.
The standout feature is the liposomal delivery system using phosphatidylcholine from sunflower oil, which aims to enhance absorption of the botanical extracts. This liquid format is a practical choice for those who have difficulty swallowing pills or prefer customizable dosing. The removal of glycyrrhizin from the licorice root reduces the risk of side effects associated with standard licorice, such as potassium loss or blood pressure elevation, making it safer for long-term use.
In terms of design, the 4-ounce amber dropper bottle is compact and travel-friendly. Each drop is approximately 0.45-0.5 mL, and the recommended 4 drops provide a 2 mL serving. The product is free from artificial additives and is based on well-researched botanical ingredients. However, as a liquid herbal supplement, it may have a strong taste that some users find unpleasant. Mixing with water or juice could help mask the flavor.
A potential drawback is the limited number of servings per bottle (60 servings at the standard dose), which means regular users might need to repurchase frequently. Additionally, the product currently has no customer reviews, so individual experiences with effectiveness and taste are not yet available. Users should consult a healthcare professional before starting any new supplement, especially those with medical conditions or taking medications.
Overall, the HesperiIyntis Liposomal DGL Licorice Root Extract offers a well-rounded, liposomal liquid option for digestive support. Its multi-ingredient formula and thoughtful design make it a compelling choice for those looking to simplify their supplement routine. While the taste may be an acquired one and the serving size limited, the quality of ingredients and innovative delivery system justify consideration for anyone prioritizing gut health.
Pros
- High-quality botanical ingredients known for soothing digestive discomfort
- Can be used as a capsule or brewed as a tea for flexible application
- Third-party certified for quality and safety
- Backed by a reputable brand trusted by professionals
- Generous 180-count bottle offers good value
Cons
- Price may be higher than some basic digestive supplements
- Taste of the tea version may be earthy or bitter for some users
- Not suitable for individuals with allergies to any of the botanical ingredients
THORNE GI Relief is a targeted digestive supplement designed for anyone experiencing gastrointestinal discomfort, including occasional heartburn, indigestion, or irritated tissues in the upper digestive tract. It combines four well-known botanical ingredients: deglycyrrhizinated licorice (DGL), slippery elm bark, marshmallow root, and aloe vera gel. This formula is especially beneficial for those seeking a natural, non-drug approach to soothe and maintain stomach and esophageal health.
The standout feature of this product is its versatility. While it comes in convenient capsule form, users can open the capsules and mix the powder with warm water to make a soothing tea. This is particularly effective for coating irritated mucous membranes in the throat and upper GI tract. The mucilaginous compounds from slippery elm and marshmallow root provide a gentle, protective layer, while DGL and aloe vera support tissue repair and reduce inflammation.
In terms of quality, THORNE is a brand that prioritizes third-party testing and certification. Each batch is verified to match the label and is free from unsafe levels of contaminants. This level of transparency builds trust, especially for consumers with sensitive digestive systems. The capsules are easy to swallow, and the 180-count bottle offers a generous supply for daily use.
Potential drawbacks include the price, which is higher than some basic fiber or antacid supplements. Additionally, the tea version may have an earthy taste that not everyone enjoys. Those with allergies to any of the botanical ingredients should avoid this product. However, for targeted relief without harsh chemicals, the investment is worthwhile.
Overall, THORNE GI Relief is a well-formulated, research-backed supplement that delivers on its promise of soothing digestive support. Its flexible format and high-quality ingredients make it a top choice for individuals looking to calm occasional GI irritation naturally. We recommend it for anyone seeking a gentle yet effective digestive aid.
Buying Guide
Form Factor: Capsules, Liquid, or Gummies?
Your preference for how you take supplements matters. Capsules, like those in THORNE GI Relief, DGL, Slippery Elm, are convenient and easy to swallow. Liquids, such as the Liposomal DGL Licorice Root Extract, Digestive, offer faster absorption and can be mixed into drinks. Gummies, exemplified by the Sugar Free DGL Stomach Smoother Gummies with DGL, are pleasant to chew but may include added sugars or fibers. For more options, see our best fiber capsules for men guide.
Ingredient Complexity: Pure vs. Multi-Botanical
Some users prefer a simple blend, while others want a comprehensive formula. THORNE’s product includes DGL, slippery elm, marshmallow root, and aloe vera. The Liposomal DGL adds L-glutamine, clove bud, and capsicum. The Sugar Free Gummies go even further with probiotics and prebiotics. If you are weighing other gut nutrients, our zinc carnosine vs L-Glutamine comparison may help.
Absorption Technology: Liposomal vs. Standard
Liposomal formulas use phospholipids to theoretically improve absorption. The Liposomal DGL from HesperiIyntis is a liquid that may deliver ingredients more efficiently. THORNE’s capsules can be opened and mixed with warm water to create a tea, allowing the mucilaginous compounds to soothe the upper digestive tract directly. Gummies rely on digestion but are convenient for daily use.
Dietary Preferences: Sugar-Free and Clean Labels
For those avoiding sugar, NutraPerfecto’s gummies are sugar-free and include prebiotic fiber. THORNE is third-party certified for purity and potency. The liquid DGL from HesperiIyntis is also free from common allergens. Always check the label for your specific needs. For more digestive health insights, visit our Best Fiber with Prebiotics post.
Final Thoughts
For those seeking a versatile, third-party verified formula, the THORNE GI Relief, DGL, Slippery Elm is a solid choice thanks to its blend of four soothing ingredients and the option to be taken as a tea. If a convenient, sugar-free daily gummy is more your style, the Sugar Free DGL Stomach Smoother Gummies with DGL offers probiotics, prebiotics, and a full botanicals lineup in one tasty serving.
Frequently Asked Questions
What is the main difference between DGL and slippery elm?
DGL is derived from licorice root with glycyrrhizin removed to avoid side effects like high blood pressure. Slippery elm comes from the inner bark of the elm tree and forms a soothing gel when mixed with water. Both coat and protect the gut lining but work through different mechanisms.
Can I take DGL and slippery elm together?
Yes, they are often combined in supplements for synergistic effects. All three products reviewed here include both DGL and slippery elm, along with other botanicals, to provide comprehensive digestive support. Always follow the recommended dosage on the label.
Which is better for acid reflux, DGL or slippery elm?
Both can help soothe irritation from acid reflux, but DGL is particularly favored for heartburn relief. Products that combine them, like the ones in this review, may offer more balanced support. For a deeper look at botanicals, see our L glutamine vs slippery elm article.
Are there any side effects of DGL or slippery elm?
Both are generally safe for most people. DGL is preferred over regular licorice for long-term use because it lacks glycyrrhizin, which can cause problems. Slippery elm may interfere with absorption of other medications if taken too close together. Always consult a healthcare provider before starting any new supplement regimen in 2026.
