When you’re shopping for omega-3, the balance between EPA and DHA often determines how well the supplement supports your heart, brain, and joints. Many capsules offer a generic 1000 mg fish oil, but if you need a higher dose of DHA specifically, the NOW Supplements, Ultra Omega-3, 500 EPA 250 DHA is designed to deliver. In this NOW DHA 500 review, we examine its potency, purity, and overall value for 2026.
We’ve compared it to other top-rated omega-3 products, such as the Thorne Omega Plus, to see where it fits. Whether you’re an athlete, a busy professional, or simply aiming to keep your mind sharp, understanding what this fish oil offers is key to making an informed choice.
Pros
- High potency EPA/DHA ratio supports both heart and brain health effectively
- Fish gelatin softgels are suitable for those avoiding mammalian gelatins
- Molecular distillation ensures a clean, high-quality oil
- Third-party GMP certification guarantees consistent quality and purity
- Long-standing brand reputation for natural products and ethical manufacturing
Cons
- Large softgel size may be difficult for some people to swallow
- Fish oil can cause mild fishy aftertaste or burps, especially if taken on an empty stomach
- Price per bottle may be higher than some lower-concentration omega-3 supplements
NOW Supplements Ultra Omega-3 is a high-potency fish oil designed for those who want a significant dose of EPA and DHA to support cardiovascular and brain health. Each softgel delivers 500 mg EPA and 250 mg DHA, making it one of the more concentrated options on the market. This product is especially suitable for health-conscious individuals, athletes, or anyone following a keto or soy-free diet.
The standout feature is its use of fish gelatin softgels, which provides an alternative to traditional bovine or porcine gelatin. The oil is molecularly distilled to remove impurities, ensuring a clean supplement. In real-world use, users report noticeable benefits in heart health markers and mental clarity, though some may experience a mild fishy aftertaste if not taken with food.
Design-wise, the softgels are amber-colored and packaged in a standard plastic bottle. While the softgels are slightly larger than some competitors, the 180-count bottle offers excellent value for daily use. NOW's commitment to quality is evident through their GMP certification and in-house ISO/IEC accredited labs, which test for stability and potency.
A potential drawback is the softgel size, which may be challenging for those who have difficulty swallowing pills. Additionally, some users might prefer a smaller serving size or a different oil source like krill. However, for most people, the benefits far outweigh these minor inconveniences.
Overall, NOW Ultra Omega-3 is a reliable and potent supplement that delivers on its promises. It's a solid choice for anyone looking to boost their omega-3 intake with a trusted brand. I recommend it for its high EPA/DHA content, clean sourcing, and ethical manufacturing.
Pros
- High concentration of EPA and DHA for strong cardiovascular support
- Added vitamin D-3 provides dual benefits for heart and immune health
- Molecular distillation ensures high purity and safety
- Pleasant lemon flavor masks fishy taste
- Trusted brand with GMP certification and third-party testing
Cons
- Large softgel size may be difficult for some people to swallow
- Includes vitamin D-3, which may not be suitable for those already taking vitamin D supplements
- Potency may be too high for omega-3 beginners
NOW Ultra Omega 3-D is a premium fish oil supplement that combines high-potency omega-3 fatty acids with vitamin D-3 in a single softgel. Each serving delivers 600 mg of EPA and 300 mg of DHA, making it one of the most potent omega-3 formulas available. This product is ideal for adults seeking comprehensive heart health and immune support.
Standout features include molecular distillation, which ensures the oil is free from harmful contaminants, and the addition of lemon oil that masks any fishy taste. The inclusion of 1,000 IU vitamin D-3 further enhances its value, offering support for bone health and immune function. This dual-action formula simplifies supplementation by combining two essential nutrients.
The softgels are manufactured under strict GMP guidelines, and the product is non-GMO and Kosher certified. NOW is a trusted brand with over 50 years of experience, and their in-house laboratories are ISO/IEC accredited, providing confidence in the product's purity and potency.
Potential drawbacks are the large size of the softgels, which may be challenging for some users to swallow. Additionally, those already taking vitamin D supplements should monitor their total intake to avoid excessive levels. It is always advisable to consult a healthcare professional before starting any new supplement.
Overall, NOW Ultra Omega 3-D is a well-rounded supplement that delivers a robust dose of omega-3s and vitamin D. It is a great choice for individuals looking to boost their cardiovascular health and overall wellness in a convenient, high-quality form.
Color: Pale Yellow
Size: 90 Count (Pack of 1)
Dimensions: 2.7 x 2.7 x 4.75 inches
Weight: 0.1984160358 pounds
Pros
- Clinical strength potency for effective prostate support
- Large 180-count bottle offers long-term value
- Trusted brand with decades of quality manufacturing
- Natural saw palmetto ingredient with minimal side effects
- Softgels are easy to swallow and digest
Cons
- May take several weeks of consistent use to notice benefits
- Not recommended for women or children
- Some users may experience mild digestive upset initially
NOW Prostate Health Clinical Strength Saw Palmetto is a dietary supplement designed specifically for men looking to support their prostate health. This product features a potent dose of saw palmetto extract, a well-known herb traditionally used to maintain healthy prostate function and urinary tract health. It is ideal for men over 40 or those experiencing occasional urinary discomfort related to prostate health.
The standout feature of this supplement is its clinical strength formulation, which delivers a higher concentration of active compounds compared to standard saw palmetto products. Each bottle contains 180 softgels, providing a convenient three-month supply when taken as directed (two softgels daily). This makes it a practical choice for long-term use without frequent reordering.
NOW Foods is a reputable brand known for its commitment to quality and purity. These softgels are made with non-GMO ingredients and are free from common allergens like gluten, soy, and dairy. The softgel design ensures easy swallowing and efficient absorption, making the supplement gentle on the stomach for most users.
One potential drawback is that saw palmetto supplements often require consistent use over several weeks before noticeable improvements in prostate comfort occur. Additionally, individual results may vary, and some men might experience mild digestive issues when first starting the regimen. It is also important to note that this product is not intended for women or children.
Overall, NOW Prostate Health Clinical Strength Saw Palmetto is a reliable and high-quality option for men seeking natural prostate support. Its potent formula, generous supply, and trusted brand reputation make it a solid choice for maintaining prostate wellness. If you are looking for a straightforward and effective saw palmetto supplement, this product is worth considering.
Pros
- High potency with 1600 mg combined DHA and EPA per serving
- Ultra-purified fish oil from Norway ensures purity and low contaminants
- Doctor formulated for targeted cognitive and immune benefits
- Gluten free and suitable for sensitive individuals
- Antioxidant and anti-inflammatory properties support overall wellness
Cons
- 30 servings per bottle may require monthly repurchase for continuous use
- Large capsule size might be challenging for some to swallow
- No flavoring or enteric coating mentioned, possible fishy aftertaste
BrainMD Omega-3 Power is a high-potency fish oil supplement designed to support brain health, joint function, and immune strength. Created by Dr. Daniel Amen, a renowned psychiatrist and brain health expert, this product targets adults who want a reliable, ultra-pure omega-3 source without synthetic additives or gluten.
Each serving provides 1600 mg of DHA and EPA from Norwegian fish oil, which is 5 times more concentrated than typical supermarket brands. In real-world use, this potency translates to faster cognitive benefits, such as improved memory and focus, as well as reduced joint stiffness. The antioxidant properties also help protect cell membranes and blood vessel linings, making it a versatile daily supplement.
The capsules are clear and medium-sized, easy to incorporate into a morning routine. BrainMD adheres to strict purity guidelines, and the product is manufactured in FDA registered facilities. Users report no fishy aftertaste when taken with meals, though individual tolerance may vary.
A potential drawback is the serving count: 30 servings per bottle (60 capsules) means a one-month supply for most users. This requires frequent repurchasing for long-term regimens. Also, those sensitive to large pills might find the capsule size slightly challenging, though it is manageable.
Overall, BrainMD Omega-3 Power is a top-tier option for anyone seeking potent, doctor-formulated omega-3 support. Its purity and potency justify the premium positioning, and it delivers on its promises for cognitive and immune health. Recommended for adults prioritizing brain function and overall wellness.
Brand: BrainMD
Model: Omega-3 Power
Servings Per Container: 30
Capsules Per Bottle: 60
Serving Size: 2 capsules
Key Ingredients: 1600 mg DHA and EPA from ultra-purified fish oil (Norway)
Form: Softgel capsule, clear color
Dietary Features: Gluten free, no artificial colors
Dimensions: 4.25 x 2.36 x 2.32 inches
Weight: 0.33 pounds
Manufacturer: BrainMD (Dr. Amen)
Pros
- High DHA concentration (500mg per softgel) for targeted support
- Excellent value with 360 softgels per pack
- Supports brain, eye, and heart health with one supplement
- Easy-to-swallow softgel design
- High customer rating (4.7 out of 5) indicating satisfaction
Cons
- Softgels may be large for individuals who have difficulty swallowing pills
- Contains fish oil, not suitable for vegetarians or vegans
- Requires consistent daily intake to achieve noticeable benefits
Now Foods DHA-500 is a high-potency omega-3 supplement designed for those who want concentrated DHA support without consuming multiple capsules. Each softgel delivers 500mg of docosahexaenoic acid, a key fatty acid for brain, eye, and cardiovascular health. This value pack includes two bottles of 180 softgels each, providing a total of 360 servings, making it a cost-effective choice for long-term use.
The standout feature is the double concentration of DHA compared to standard fish oil supplements. This allows users to get their daily DHA intake with fewer pills, which is convenient for busy lifestyles. The softgels are easy to swallow and have a smooth texture, reducing the risk of gagging. Many users report improved focus and memory after consistent use, though individual results may vary.
Design and build quality are solid. The softgels are manufactured in a GMP-certified facility and are tested for purity and potency. They are free from artificial preservatives and common allergens like gluten and soy. The bottles are opaque to protect the oil from light degradation, and a tamper-evident seal ensures freshness. However, the capsules are gelatin-based, so they are not vegan-friendly.
Potential drawbacks include the size of the softgels, which may be challenging for some to swallow. Additionally, those sensitive to fish oil might experience mild aftertaste or burping, though taking them with meals can help. The product requires no refrigeration but should be stored in a cool, dry place to maintain potency.
Overall, Now Foods DHA-500 is an excellent choice for anyone seeking a high-dose DHA supplement for cognitive and cardiovascular support. The value pack offers great savings, and the brand's reputation for quality adds peace of mind. It is particularly suited for adults, students, and older individuals who prioritize brain health.
Buying Guide
EPA and DHA Dosage
The most critical factor in any fish oil supplement is the amount of EPA and DHA it provides. The NOW Ultra Omega-3 packs 500 mg of EPA and 250 mg of DHA per softgel, offering a 2:1 ratio that supports cardiovascular health and cognitive function. This concentrated dose means you need fewer capsules to hit your daily target, especially if you’re aiming for 1000 mg of combined EPA and DHA.
Compared to standard fish oils that might have 180 mg EPA and 120 mg DHA, this product is about twice as potent. For a detailed look at another high-potency option, see our life extension mega EPA DHA review.
Purity and Molecular Distillation
Toxins like mercury and PCBs are a concern with any fish oil. NOW uses molecular distillation to remove impurities, ensuring a clean product that’s safe for daily use. This process also helps to reduce the fishy aftertaste and oxidation, which can be a turn-off for many.
If you’re concerned about environmental contaminants, this product is third-party verified and carries the GOED seal, which indicates adherence to strict quality standards. For more on how purity affects overall health, check out our guide on supplements for healthy blood flow.
Softgel Type and Dietary Preferences
Most fish oil supplements use bovine or porcine gelatin, but NOW has opted for fish gelatin to cater to those who avoid land-animal byproducts. This is a thoughtful inclusion for pescatarians or those with certain dietary restrictions.
The softgels are also free from soy, making them suitable for those with soy allergies. If you’re exploring plant-based options, you might want to compare with other products, but this fish gelatin alternative is a nice feature.
Brand Reputation and Certifications
NOW has been a trusted name in supplements since 1968, and they are one of the largest independent and employee-owned manufacturers. Their commitment to quality is reflected in their GMP certification and ISO/IEC accredited labs, which verify the potency and purity of each batch.
When you choose NOW, you’re getting a product that’s been reviewed and trusted by countless users. For a comparison with another top brand, read our life extension super omega 3 plus review to see how they compare.
Final Thoughts
Overall, we are impressed with the NOW Supplements, Ultra Omega-3, 500 EPA 250 DHA. It delivers a potent and pure dose of omega-3s in a fish gelatin softgel, making it a versatile choice for anyone looking to boost their DHA intake. We recommend the NOW Supplements, Ultra Omega-3, 500 EPA 250 DHA for its balance of EPA and DHA, and for those who prefer a fish gelatin option, the same NOW Ultra Omega-3 is equally excellent.
Frequently Asked Questions
What is DHA and why is it important?
DHA (docosahexaenoic acid) is an omega-3 fatty acid that is crucial for brain function, eye health, and inflammation control. Since the body can’t make it in large amounts, getting it from diet or supplements is key. In 2026, more studies are highlighting its role in cognitive health. For more on omega-3’s benefits, see our article on essential nutrients for healthy circulation.
How much EPA and DHA is in NOW Ultra Omega-3?
Each softgel contains 500 mg of EPA and 250 mg of DHA, giving you a 750 mg total of omega-3s per serving. This is a concentrated dose that allows you to take fewer pills to reach your target intake.
Is fish gelatin suitable for vegetarians?
No, fish gelatin comes from fish skin and bones, so it’s not vegetarian. However, it’s a good alternative for those who avoid bovine or porcine gelatin. If you’re strictly vegetarian, you’ll need to look for algal oil supplements instead.
Can I take this with other supplements?
Yes, fish oil is generally safe to combine with most supplements, including multivitamins and magnesium. However, if you’re on blood-thinning medication, consult your doctor first because omega-3s can have a mild blood-thinning effect.
